Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Melengestrol Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 7/20 | 0.72 |
| ▸ | LMNA | P02545 | 6/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | AR | P10275 | 7/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Melengestrol Acetate SCHEMBL15079259 | 0.86 | LMNA (1.00) | LMNAMEN1KMT2ATDP1AR | |
| Melengestrol Acetate SCHEMBL16389279 | 0.86 | LMNA (1.00) | LMNAMEN1KMT2ATDP1AR | |
| Melengestrol Acetate SCHEMBL13778228 | 0.86 | LMNA (1.00) | LMNAMEN1KMT2ATDP1AR | |
| Melengestrol Acetate SCHEMBL4520 | 0.86 | LMNA (1.00) | LMNAMEN1KMT2ATDP1AR | |
| Melengestrol Acetate SCHEMBL10867312 | 0.86 | LMNA (1.00) | LMNAMEN1KMT2ATDP1AR | |
| Nomegestrol Acetate SCHEMBL19760877 | 0.85 | PGR (1.00) | LMNAMEN1KMT2ATDP1AR | |
| Nomegestrol Acetate SCHEMBL8817628 | 0.85 | PGR (1.00) | LMNAMEN1KMT2ATDP1AR | |
| Nomegestrol Acetate SCHEMBL37517 | 0.85 | PGR (1.00) | LMNAMEN1KMT2ATDP1AR | |
| Megestrol Acetate SCHEMBL13660184 | 0.82 | AR (1.00) | LMNAMEN1KMT2ATDP1AR | |
| Megestrol Acetate SCHEMBL21281326 | 0.82 | AR (1.00) | LMNAMEN1KMT2ATDP1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1429104-A | Inhibitors of 17 beta-hydroxysteroid dehydrogenase type 5 and 3 and methods of use thereof | ENDORECH INC (CA) | 2003-07-09 | — | — | CN | claimed |
| EP-1094798-A2 | INHIBITORS OF TYPE 5 AND TYPE 3 17beta-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE | Endorecherche Inc. (CA) | 2001-05-02 | — | — | EP | claimed |
| WO-1999046279-A2 | INHIBITORS OF TYPE 5 AND TYPE 3 17β-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE | ENDORECHERCHE, INC. (CA) | 1999-09-16 | — | — | WO | claimed |
| CN-1429104-A | Inhibitors of 17 beta-hydroxysteroid dehydrogenase type 5 and 3 and methods of use thereof | ENDORECH INC (CA) | 2003-07-09 | — | — | CN | disclosed |
| EP-1094798-A2 | INHIBITORS OF TYPE 5 AND TYPE 3 17beta-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE | Endorecherche Inc. (CA) | 2001-05-02 | — | — | EP | disclosed |
| WO-1999046279-A2 | INHIBITORS OF TYPE 5 AND TYPE 3 17β-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE | ENDORECHERCHE, INC. (CA) | 1999-09-16 | — | — | WO | disclosed |