Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758410 | 0.86 | HTR1A (0.53) | MEN1KMT2ADRD2DRD4HTR7 | |
| SCHEMBL7760241 | 0.85 | MEN1 (0.54) | MEN1KMT2ADRD2DRD4CHRM4 | |
| SCHEMBL6068291 | 0.85 | MEN1 (0.48) | MEN1KMT2ADRD2DRD4CHRM4 | |
| SCHEMBL7955962 | 0.80 | HTR1A (0.42) | MEN1KMT2ADRD2CHRM4MAPK1 | |
| SCHEMBL7155140 | 0.77 | MEN1 (0.54) | MEN1KMT2ADRD2DRD4CHRM4 | |
| SCHEMBL6068330 | 0.77 | MEN1 (0.54) | MEN1KMT2ADRD2DRD4CHRM4 | |
| SCHEMBL6068222 | 0.75 | DRD2 (0.53) | MEN1KMT2ADRD2DRD4CHRM4 | |
| SCHEMBL6068249 | 0.75 | DRD2 (0.55) | MEN1KMT2ADRD2DRD4MAPK1 | |
| SCHEMBL6068487 | 0.75 | MEN1 (0.49) | MEN1KMT2ADRD2DRD4CHRM4 | |
| SCHEMBL6177901 | 0.74 | MEN1 (0.50) | MEN1KMT2ADRD2DRD4CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087954-A1 | CYCLOALKYL-SUBSTITUTED ARYL-PIPERAZINES, PIPERIDINES AND TETRAHYDROPYRIDINES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-04-04 | — | — | EP | claimed |
| WO-1999065887-A1 | CYCLOALKYL-SUBSTITUTED ARYL-PIPERAZINES, PIPERIDINES AND TETRAHYDROPYRIDINES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-23 | — | — | WO | claimed |