Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760241 | 0.88 | MEN1 (0.54) | MEN1KMT2ADRD2CHRM4DRD4 | |
| SCHEMBL7759804 | 0.85 | MEN1 (0.46) | MEN1KMT2ADRD2CHRM4DRD4 | |
| SCHEMBL6068487 | 0.80 | MEN1 (0.49) | MEN1KMT2ADRD2CHRM4DRD4 | |
| SCHEMBL7155140 | 0.79 | MEN1 (0.54) | MEN1KMT2ADRD2CHRM4DRD4 | |
| SCHEMBL6068330 | 0.79 | MEN1 (0.54) | MEN1KMT2ADRD2CHRM4DRD4 | |
| SCHEMBL6068249 | 0.77 | DRD2 (0.55) | MEN1KMT2ADRD2DRD4MAPK1 | |
| SCHEMBL6068222 | 0.75 | DRD2 (0.53) | MEN1KMT2ADRD2CHRM4DRD4 | |
| SCHEMBL6068218 | 0.75 | DRD2 (0.53) | MEN1KMT2ADRD2DRD4MAPK1 | |
| Cyclohexane SCHEMBL6180435 | 0.73 | MEN1 (0.48) | MEN1KMT2ADRD2CHRM4DRD4 | |
| SCHEMBL6177728 | 0.73 | HTR1A (0.56) | MEN1KMT2ADRD2CHRM4DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049330-B2 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (US) | 2006-05-23 | — | — | US | claimed |
| US-20030139449-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (US) | 2003-07-24 | — | — | US | claimed |
| US-20020156075-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (FORMERLY AMERICAN HOME PRODUCTS CORPORATION) (US) | 2002-10-24 | — | — | US | claimed |
| US-7049330-B2 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (US) | 2006-05-23 | — | — | US | disclosed |
| US-20030139449-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (US) | 2003-07-24 | — | — | US | disclosed |
| US-6518272-B2 | HT3 receptor agonists and antagonists; treatment of anxiety, depression, cognitive deficits, and prostate cancer | WYETH | 2003-02-11 | — | — | US | disclosed |
| US-20020156075-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (FORMERLY AMERICAN HOME PRODUCTS CORPORATION) (US) | 2002-10-24 | — | — | US | disclosed |
| US-6376494-B1 | USED IN THE TREATMENT OF ANXIETY AND DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139449-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | HTR5A, MC5R, CHRNA5 | MEN1 2716/4885KMT2A 3539/4885DRD2 59/4885 |
| US-20020156075-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | HTR5A, MC5R, CHRNA5 | MEN1 2716/4885KMT2A 3539/4885DRD2 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.