Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760879 | 0.87 | MAPT (0.53) | MAPTNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL6293768 | 0.82 | KDM4E (0.60) | MAPTNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL7760889 | 0.81 | MEN1 (0.56) | NPC1RAB9ASMN1; SMN2MAPK1KMT2A | |
| SCHEMBL7761944 | 0.81 | KMT2A (0.67) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7756925 | 0.79 | NPC1 (0.49) | MAPTNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL7300289 | 0.76 | MAPT (0.62) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL8495430 | 0.73 | MAPT (0.50) | MAPTNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL3083077 | 0.72 | NTRK1 (0.57) | ALDH1A1ATM | |
| SCHEMBL7760048 | 0.71 | MAPT (0.50) | MAPTNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL8574185 | 0.71 | MAPT (0.41) | MAPTNPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541479-B1 | Derivatives of thiosalicylic acid and o-aminobenzoic acid | MASSACHUSETTS COLLEGE OF PHARMACY | 2003-04-01 | — | — | US | disclosed |