Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SNCA | P37840 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297699 | 0.87 | MEN1 (0.61) | MAPTALDH1A1SMN1; SMN2RAB9ASNCA | |
| SCHEMBL7288495 | 0.84 | KMT2A (0.70) | ALDH1A1L3MBTL1KMT2ALMNAHPGD | |
| SCHEMBL7761944 | 0.83 | KMT2A (0.67) | MAPTSMN1; SMN2RAB9ASNCAL3MBTL1 | |
| SCHEMBL7760879 | 0.78 | MAPT (0.53) | MAPTALDH1A1SMN1; SMN2RAB9ASNCA | |
| SCHEMBL6169126 | 0.78 | ALDH1A1 (0.80) | MAPTALDH1A1SMN1; SMN2RAB9ASNCA | |
| SCHEMBL8495430 | 0.77 | MAPT (0.50) | MAPTALDH1A1SMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL7760034 | 0.76 | MAPT (0.51) | MAPTALDH1A1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6171613 | 0.76 | RAB9A (1.00) | MAPTALDH1A1SMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL9370863 | 0.76 | ALDH1A1 (0.88) | MAPTALDH1A1SMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL11357236 | 0.75 | KMT2A (0.51) | MAPTALDH1A1L3MBTL1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116851-A | Administering antiischemic and antiarrhythmia agents | E. R. SQUIBB & SONS, INC. (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0453658-A2 | Use of substituted anilides and sulfonamides in the treatment of cardiovascular diseases | E.R. SQUIBB & SONS, INC. (US) | 1991-10-30 | — | — | EP | disclosed |