Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7721962 | 0.83 | PLG (0.33) | DGAT1LMNA | |
| SCHEMBL27950403 | 0.72 | GAA (0.41) | DGAT1GAAEPHX1SSTR4HPGD | |
| SCHEMBL1372061 | 0.71 | DGAT1 (0.46) | DGAT1GAAEPHX1SSTR4HPGD | |
| SCHEMBL3983126 | 0.71 | MEN1 (0.37) | EPHX1SSTR4MEN1ALDH1A1LMNA | |
| SCHEMBL20635363 | 0.71 | DGAT1 (0.43) | DGAT1GAAEPHX1SSTR4HPGD | |
| SCHEMBL6597535 | 0.70 | DGAT1 (0.42) | DGAT1GAAEPHX1SSTR4HPGD | |
| SCHEMBL28077248 | 0.69 | DGAT1 (0.45) | DGAT1GAAEPHX1SSTR4HPGD | |
| SCHEMBL6886101 | 0.69 | GAA (0.43) | GAAEPHX1SSTR4BTK | |
| SCHEMBL6512299 | 0.68 | DGAT1 (0.41) | DGAT1GAAEPHX1HPGDBTK | |
| SCHEMBL26605075 | 0.68 | DGAT1 (0.37) | DGAT1GAAEPHX1SSTR4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087940-A1 | NOVEL COMPOUNDS USEFUL IN PAIN MANAGEMENT | AstraZeneca AB (SE) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999067203-A1 | NOVEL COMPOUNDS USEFUL IN PAIN MANAGEMENT | ASTRAZENECA AB (SE) | 1999-12-29 | — | — | WO | disclosed |