Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSH | P09668 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7761961 | 1.00 | HDAC3 (0.43) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| Trifluoroacetic Acid SCHEMBL9080870 | 0.94 | KDM4E (0.42) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL7763332 | 0.83 | TRPA1 (0.42) | CTSKCTSLCTSBCTSHALDH1A1 | |
| SCHEMBL7763374 | 0.83 | TRPA1 (0.46) | CTSKCTSLCTSBCTSHALDH1A1 | |
| SCHEMBL7760075 | 0.83 | TRPA1 (0.46) | CTSKCTSLCTSBCTSHALDH1A1 | |
| SCHEMBL7760073 | 0.83 | TRPA1 (0.42) | CTSKCTSLCTSBCTSHALDH1A1 | |
| SCHEMBL12358871 | 0.82 | CTSK (0.42) | CTSKCTSLCTSBCTSHMEN1 | |
| SCHEMBL7779594 | 0.80 | TRPA1 (0.46) | HDAC3HDAC1HDAC2HDAC8CTSK | |
| SCHEMBL7756946 | 0.79 | TRPA1 (0.44) | ALDH1A1 | |
| SCHEMBL12358872 | 0.78 | FDFT1 (0.41) | CTSKCTSLCTSBCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821665-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1090908-A2 | Cyclobutane derivatives as inhibitors of protein farnesyltransferase | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | disclosed |