Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | FDFT1 | P37268 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSH | P09668 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760075 | 1.00 | TRPA1 (0.46) | TRPA1TSHRCYP3A4FDFT1CYP2D6 | |
| SCHEMBL7763332 | 0.89 | TRPA1 (0.42) | TRPA1TSHRFDFT1CYP2D6NPC1 | |
| SCHEMBL7760073 | 0.89 | TRPA1 (0.42) | TRPA1TSHRFDFT1CYP2D6NPC1 | |
| SCHEMBL7779594 | 0.85 | TRPA1 (0.46) | TRPA1TSHRFDFT1CYP2D6NPC1 | |
| SCHEMBL12358871 | 0.85 | CTSK (0.42) | TRPA1TSHRFDFT1CYP2D6NPC1 | |
| SCHEMBL7756946 | 0.84 | TRPA1 (0.44) | TRPA1TSHRFDFT1CYP2D6NPC1 | |
| SCHEMBL7761961 | 0.83 | HDAC3 (0.43) | CTSKCTSLCTSBCTSHALDH1A1 | |
| SCHEMBL7761017 | 0.83 | HDAC3 (0.43) | CTSKCTSLCTSBCTSHALDH1A1 | |
| SCHEMBL12358872 | 0.81 | FDFT1 (0.41) | TRPA1FDFT1CTSKCTSLCTSB | |
| SCHEMBL14341043 | 0.81 | TRPA1 (0.46) | TRPA1TSHRFDFT1CYP2D6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821665-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1090908-A2 | Cyclobutane derivatives as inhibitors of protein farnesyltransferase | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | disclosed |
| US-5831115-A | CYCLOBUTANECARBOXAMIDES | ABBOTT LABORATORIES (US) | 1998-11-03 | — | — | US | disclosed |