Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048462 | 0.84 | POLB (0.39) | TDP1POLBMAPTKMT2AMEN1 | |
| SCHEMBL1149742 | 0.83 | KDM4E (0.48) | TDP1POLBMAPTALDH1A1KMT2A | |
| SCHEMBL9890969 | 0.83 | POLB (0.38) | TDP1POLBMAPTALDH1A1MAPK1 | |
| SCHEMBL27614341 | 0.83 | POLB (0.48) | TDP1SIRT3PKMYT1NNMTPOLB | |
| SCHEMBL354227 | 0.82 | SIRT3 (0.45) | TDP1SIRT3PKMYT1NNMTMAPT | |
| SCHEMBL11457957 | 0.81 | POLB (0.37) | TDP1PKMYT1POLBMAPTALDH1A1 | |
| SCHEMBL10800974 | 0.81 | KDM4E (0.47) | TDP1POLBMAPTALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL27784477 | 0.81 | POLB (0.46) | TDP1SIRT3PKMYT1NNMTPOLB | |
| Hydrochloric Acid SCHEMBL1776795 | 0.80 | SIRT3 (0.44) | TDP1SIRT3PKMYT1NNMTMAPT | |
| SCHEMBL17818478 | 0.79 | ERN1 (0.44) | TDP1SIRT3NNMTMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108191822-A | A kind of synthetic method of Rynaxypyr | 广东丸美生物技术股份有限公司 | 2018-06-22 | — | — | CN | claimed |
| WO-2021111311-A2 | NOVEL ADAMANTANE DERIVATIVES AS INHIBITORS OF FOCAL ADHESION KINASE | 삼진제약주식회사 | 2021-06-10 | — | — | WO | disclosed |
| CN-108191822-A | A kind of synthetic method of Rynaxypyr | 广东丸美生物技术股份有限公司 | 2018-06-22 | — | — | CN | disclosed |
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS (US) | 2016-06-16 | — | — | US | disclosed |
| US-8754105-B2 | Macrocyclic inhibitors of hepatitis C virus | MEDIVIR AB (SE) | 2014-06-17 | — | — | US | disclosed |
| US-20110237621-A1 | Macrocyclic Inhibitors of Hepatitis C Virus | JANSSEN SCIENCES IRELAND UC (IE) | 2011-09-29 | — | — | US | disclosed |
| US-7989471-B2 | Macrocyclic inhibitors of hepatitis C virus | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2011-08-02 | — | — | US | disclosed |
| US-20100240698-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS | JANSSEN SCIENCES IRELAND UC (IE) | 2010-09-23 | — | — | US | disclosed |
| CN-1127493-C | 1-(N-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of phenyl ring | RECORDATI CHEM PHARM (CH) | 2003-11-12 | — | — | CN | disclosed |
| US-6331627-B1 | Intermediates of benzoxazinone derivatives and preparation thereof | REDDY'S LABORATORIES LTD. (IN) | 2001-12-18 | — | — | US | disclosed |
| CN-1312817-A | Dolastatin 15 derivatives | BASF AG (DE) | 2001-09-12 | — | — | CN | disclosed |
| EP-1093460-A1 | DOLASTATIN 15 DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-04-25 | — | — | EP | disclosed |
| CN-1280574-A | Heterocyclic compounds, their use in medicine, processes for their preparation and pharmaceutical compositions containing them | REDDY CHEMINOR INC (IN) | 2001-01-17 | — | — | CN | disclosed |
| CN-1265654-A | 1-(N-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of phenyl ring | RECORDATI CHEM PHARM (CH) | 2000-09-06 | — | — | CN | disclosed |
| WO-2000002906-A1 | DOLASTATIN 15 DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-20 | — | — | WO | disclosed |
| EP-0084853-B1 | PROCESS FOR THE PREPARATION OF 1,8-NAPHTHOLACTAM COMPOUNDS | CIBA-GEIGY AG (CH) | 1986-11-12 | — | — | EP | disclosed |
| US-4515963-A | AMIDATIUON OF NAPHTHOLACTONE | CIBA GEIGY AG (CH) | 1985-05-07 | — | — | US | disclosed |
| EP-0084853-A1 | Process for the preparation of 1,8-naphtholactam compounds | CIBA-GEIGY AG (CH) | 1983-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | FOS, FOSB, YAP1 | TDP1 3875/4885SIRT3 3002/4885PKMYT1 783/4885 |
| US-20110237621-A1 | Macrocyclic Inhibitors of Hepatitis C Virus | NR4A1, NR4A3, NR4A2 | TDP1 4840/4885SIRT3 2272/4885PKMYT1 4384/4885 |
| US-20100240698-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS | CYP2B6, SRD5A1, NR5A2 | TDP1 4836/4885SIRT3 1672/4885PKMYT1 4120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.