Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 1.00 |
| ▸ | MMP3 | P08254 | 7/20 | 1.00 |
| ▸ | MMP7 | P09237 | 6/20 | 1.00 |
| ▸ | MMP2 | P08253 | 12/20 | 0.60 |
| ▸ | MMP9 | P14780 | 9/20 | 0.60 |
| ▸ | MMP8 | P22894 | 8/20 | 0.60 |
| ▸ | MMP13 | P45452 | 4/20 | 0.54 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.54 |
| ▸ | FCER2 | P06734 | 3/20 | 0.53 |
| ▸ | MMP12 | P39900 | 2/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763096 | 0.89 | MMP3 (0.80) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7758424 | 0.84 | MMP1 (0.73) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL6811143 | 0.84 | MMP1 (0.73) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7451414 | 0.83 | MMP1 (0.71) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7762316 | 0.82 | MMP2 (0.75) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7758531 | 0.82 | MMP1 (0.69) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL6806856 | 0.82 | MMP1 (0.69) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7762371 | 0.76 | MMP3 (0.61) | MMP1MMP3MMP7MMP2FCER2 | |
| SCHEMBL7763149 | 0.76 | MMP1 (0.61) | MMP1MMP3MMP7MMP2MMP9 | |
| SCHEMBL7758581 | 0.76 | MMP3 (0.61) | MMP1MMP3MMP7MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | claimed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | claimed |
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |