Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 15/20 | 0.62 |
| ▸ | MMP2 | P08253 | 13/20 | 0.62 |
| ▸ | MMP1 | P03956 | 10/20 | 0.59 |
| ▸ | MMP7 | P09237 | 4/20 | 0.59 |
| ▸ | MMP9 | P14780 | 3/20 | 0.59 |
| ▸ | Q9HBH1 | 1/20 | 0.56 | |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7761449 | 0.87 | MMP2 (0.83) | MMP3MMP2MMP1MMP9MMP14 | |
| SCHEMBL7758470 | 0.86 | MMP2 (0.75) | MMP3MMP2MMP1MMP9MMP14 | |
| SCHEMBL7762285 | 0.78 | MMP2 (0.82) | MMP3MMP2 | |
| SCHEMBL7763178 | 0.76 | MMP2 (0.74) | MMP3MMP2 | |
| SCHEMBL4816160 | 0.76 | MMP2 (0.70) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL7758581 | 0.75 | MMP3 (0.61) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL14545737 | 0.75 | MMP3 (1.00) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL8398532 | 0.75 | MMP3 (1.00) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL4818599 | 0.73 | MMP3 (0.82) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL7762136 | 0.73 | MMP1 (1.00) | MMP3MMP2MMP1MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | claimed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | claimed |
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |