Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767125 | 0.87 | CA1 (0.33) | ALDH1A1 | |
| SCHEMBL7768507 | 0.82 | ALDH1A1 (0.49) | ALDH1A1HPGDMEN1NPC1RAB9A | |
| SCHEMBL7767007 | 0.82 | HTT (0.43) | ALDH1A1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7767002 | 0.75 | ALDH1A1 (0.52) | ALDH1A1HPGDMEN1NPC1RAB9A | |
| SCHEMBL7767603 | 0.74 | ALDH1A1 (0.45) | ALDH1A1HPGDMEN1GAAKMT2A | |
| SCHEMBL7767566 | 0.74 | LTA4H (0.40) | ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7767564 | 0.73 | CASP1 (0.43) | ALDH1A1HPGDMEN1NPC1HSP90AA1 | |
| SCHEMBL7768555 | 0.72 | ALDH1A1 (0.41) | ALDH1A1HPGDNPC1RAB9AL3MBTL1 | |
| SCHEMBL7763927 | 0.71 | ALDH1A1 (0.47) | ALDH1A1HPGDMEN1NPC1GAA | |
| SCHEMBL7769000 | 0.71 | HTT (0.36) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| US-5830920-A | PREVENTION GROWTH OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |