Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7769000 | 0.88 | HTT (0.36) | HTTSMN1; SMN2STAT3ALOX5ALDH1A1 | |
| SCHEMBL7767591 | 0.84 | MAOB (0.46) | SMN1; SMN2ALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL7763871 | 0.82 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MEN1NPC1RAB9A | |
| SCHEMBL7768507 | 0.80 | ALDH1A1 (0.49) | HTTSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL7763838 | 0.76 | DRD2 (0.43) | SMN1; SMN2ALDH1A1MAPTLMNAMAOB | |
| SCHEMBL7767002 | 0.73 | ALDH1A1 (0.52) | HTTSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL7767603 | 0.72 | ALDH1A1 (0.45) | ALDH1A1MAPTMAPK1TDP1MRGPRX4 | |
| SCHEMBL15658850 | 0.72 | ALDH1A1 (0.43) | HTTALDH1A1LMNA | |
| SCHEMBL28687044 | 0.72 | ALOX5 (0.60) | HTTSMN1; SMN2STAT3ALOX5MAPT | |
| SCHEMBL7771475 | 0.72 | MEN1 (0.53) | ALOX5ALDH1A1MRGPRX4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| US-5830920-A | PREVENTION GROWTH OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |