Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 6/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7764032 | 1.00 | CES2 (0.62) | CES2MAPTL3MBTL1ACHEMETAP1 | |
| SCHEMBL4808970 | 0.84 | MIF (0.61) | CES2ACHEMETAP1MAOAMAOB | |
| SCHEMBL4808965 | 0.84 | MIF (0.61) | CES2ACHEMETAP1MAOAMAOB | |
| SCHEMBL10692866 | 0.80 | MAPT (0.55) | CES2MAPTL3MBTL1METAP1KDM4E | |
| SCHEMBL6392453 | 0.77 | ALDH1A1 (0.50) | CES2MAPTL3MBTL1METAP1KDM4E | |
| SCHEMBL6392459 | 0.77 | ALDH1A1 (0.50) | CES2MAPTL3MBTL1METAP1KDM4E | |
| SCHEMBL28220585 | 0.77 | CES2 (1.00) | CES2MAOAMAOB | |
| SCHEMBL28220590 | 0.77 | CES2 (1.00) | CES2MAOAMAOB | |
| SCHEMBL28585350 | 0.77 | MAOA (0.55) | CES2MAPTL3MBTL1METAP1MAOA | |
| SCHEMBL4899699 | 0.76 | NQO1 (0.52) | CES2MAPTL3MBTL1METAP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700905-B1 | Tricyclic pyrazole derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5561150-A | 1-AMINOALKYL-1,4-DIHYDROINDENO(2,1-C)PYRAZOLES OR 1H-BENZ(G)INDAZOLES; SEROTONIN RECEPTOR ANTAGONISTS; ANTIDEPRESSANTS; NERVOUS SYSTEM, PSYCHOLOGICAL AND GASTROINTESTINAL DISORDERS | HOFFMAN-LA ROCHE INC. (US) | 1996-10-01 | — | — | US | disclosed |
| EP-0700905-A1 | Tricyclic pyrazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1996-03-13 | — | — | EP | disclosed |