Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HNF4A | P41235 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508095 | 0.82 | HDAC4 (0.45) | HDAC4HDAC2HDAC8HDAC6HNF4A | |
| SCHEMBL57735 | 0.81 | ALDH1A1 (0.42) | HDAC4HDAC2HDAC8HDAC6HNF4A | |
| SCHEMBL932550 | 0.80 | ESR2 (0.58) | HDAC4HDAC2HDAC8HDAC6HNF4A | |
| SCHEMBL9162349 | 0.78 | CA2 (0.38) | ALDH1A1HSD17B10HPGD | |
| SCHEMBL30605196 | 0.78 | HDAC4 (0.65) | HDAC4HDAC2HDAC8HDAC6HNF4A | |
| SCHEMBL60283 | 0.78 | HDAC4 (0.65) | HDAC4HDAC2HDAC8HDAC6HNF4A | |
| SCHEMBL1644568 | 0.78 | ALDH1A1 (0.39) | HDAC4HDAC2HDAC8HDAC6HNF4A | |
| SCHEMBL11393405 | 0.76 | CYP2A6 (0.45) | HDAC4HDAC2HDAC8HDAC6HNF4A | |
| SCHEMBL7573005 | 0.76 | ALDH1A1 (0.45) | HDAC4HDAC2HDAC8HDAC6HNF4A | |
| SCHEMBL11390626 | 0.76 | PDCD1 (0.48) | HDAC4HDAC2HDAC8HDAC6HNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100484-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2001-05-23 | — | — | EP | claimed |
| WO-2000003704-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-27 | — | — | WO | claimed |