Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13016622 | 0.86 | PARP1 (0.50) | LTA4HADORA3CHRM3ACEALDH1A1 | |
| SCHEMBL16269854 | 0.86 | PARP1 (0.50) | LTA4HADORA3CHRM3ACEALDH1A1 | |
| SCHEMBL7766535 | 0.83 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL30977670 | 0.80 | LTA4H (0.46) | LTA4HADORA3ALDH1A1 | |
| SCHEMBL28468245 | 0.78 | KMT2A (0.52) | LTA4HADORA3ACEALDH1A1KMT2A | |
| SCHEMBL3337396 | 0.78 | OPRD1 (0.39) | LTA4HNR1I2ADORA3HTTKCNH2 | |
| SCHEMBL3337402 | 0.78 | OPRD1 (0.39) | LTA4HNR1I2ADORA3HTTKCNH2 | |
| SCHEMBL7137211 | 0.78 | LTA4H (0.71) | LTA4HNPC1LMNARAB9AACE | |
| SCHEMBL6004077 | 0.76 | LTA4H (0.55) | LTA4HLMNASCN1ASCN2ASCN3A | |
| SCHEMBL6974241 | 0.75 | LTA4H (0.40) | LTA4HADORA3CHRM3ACHEKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105412-A1 | SERINE PROTEASE INHIBITORS COMPRISING ALPHA-KETO HETEROCYCLES | CORTECH, INC. (US) | 2001-06-13 | — | — | EP | disclosed |
| US-6159938-A | Serine protease inhibitors comprising α-keto heterocycles | CORTECH, INC. | 2000-12-12 | — | — | US | disclosed |
| WO-2000009542-A1 | SERINE PROTEASE INHIBITORS COMPRISING α-KETO HETEROCYCLES | CORTECH, INC. (US) | 2000-02-24 | — | — | WO | disclosed |