Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7764601 | 0.83 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BALDH1A1KMT2A | |
| SCHEMBL23723317 | 0.82 | ALDH1A1 (0.52) | ALDH1A1KMT2ATDP1CYP1A2CYP2C19 | |
| SCHEMBL12302263 | 0.82 | ALDH1A1 (0.52) | ALDH1A1KMT2ATDP1CYP1A2CYP2C19 | |
| SCHEMBL12634745 | 0.82 | ALDH1A1 (0.52) | ALDH1A1KMT2ATDP1CYP1A2CYP2C19 | |
| SCHEMBL6103069 | 0.81 | ALDH1A1 (0.52) | ADRA1DADRA1AADRA1BALDH1A1KMT2A | |
| SCHEMBL8669709 | 0.80 | DRD2 (0.56) | ADRA1AKMT2ADRD2HTR1AHTR2A | |
| SCHEMBL7412297 | 0.80 | ALDH1A1 (0.51) | ALDH1A1KMT2ACYP1A2SIGMAR1 | |
| SCHEMBL2027557 | 0.80 | ALDH1A1 (0.51) | ALDH1A1KMT2ACYP1A2SIGMAR1 | |
| SCHEMBL1818139 | 0.80 | ALDH1A1 (0.51) | ALDH1A1KMT2ACYP1A2SIGMAR1 | |
| SCHEMBL1116547 | 0.80 | ALDH1A1 (0.56) | ALDH1A1HTR2ACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105412-A1 | SERINE PROTEASE INHIBITORS COMPRISING ALPHA-KETO HETEROCYCLES | CORTECH, INC. (US) | 2001-06-13 | — | — | EP | disclosed |
| US-6159938-A | Serine protease inhibitors comprising α-keto heterocycles | CORTECH, INC. | 2000-12-12 | — | — | US | disclosed |
| WO-2000009542-A1 | SERINE PROTEASE INHIBITORS COMPRISING α-KETO HETEROCYCLES | CORTECH, INC. (US) | 2000-02-24 | — | — | WO | disclosed |