Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PIN1 | Q13526 | 5/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532641 | 0.95 | KDM4E (0.47) | KDM4EMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL7411194 | 0.82 | PTPRC (0.47) | MEN1KMT2AALDH1A1MAPTPKM | |
| SCHEMBL4442412 | 0.80 | SLC1A2 (0.54) | KMT2AALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL7566579 | 0.79 | TTR (0.51) | MEN1KMT2AALDH1A1MAPTPKM | |
| SCHEMBL27568636 | 0.78 | CES2 (0.53) | KDM4EMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL31030764 | 0.76 | MEN1 (0.61) | KDM4EMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL7477122 | 0.76 | NPC1 (0.56) | KDM4EMEN1KMT2AALDH1A1PIN1 | |
| SCHEMBL9595514 | 0.75 | PIN1 (0.49) | KDM4EMEN1KMT2AALDH1A1EGFR | |
| SCHEMBL8416550 | 0.75 | SLC1A2 (0.69) | PIN1CES2CES1DEGS1NR1H4 | |
| SCHEMBL1149678 | 0.73 | NPC1 (0.62) | KDM4EMEN1KMT2AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873329-B1 | NOVEL N-AMINOALKYLFLUORENECARBOXAMIDES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORP (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-1081142-A2 | Novel N-Aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands | NEUROGEN CORPORATION (US) | 2001-03-07 | — | — | EP | disclosed |
| US-6015900-A | FOR TREATMENT OF PSYCHOTIC OR CENTRAL NERVOUS SYSTEM DISORDERS | NEUROGEN CORPORATION (US) | 2000-01-18 | — | — | US | disclosed |
| US-5932734-A | HIGH AFFINITY AND SELECTIVITY IN BINDING TO THE D3 RECEPTOR SUBTYPE; PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0873329-A1 | NOVEL N-AMINOALKYLFLUORENECARBOXAMIDES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-10-28 | — | — | EP | disclosed |
| US-5659033-A | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1997010229-A1 | NOVEL N-AMINOALKYLFLUORENECARBOXAMIDES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1997-03-20 | — | — | WO | disclosed |