Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 5/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7765340 | 0.95 | KDM4E (0.53) | KDM4EMEN1ALDH1A1EGFRTP53 | |
| SCHEMBL7411194 | 0.81 | PTPRC (0.47) | MEN1ALDH1A1MAPTPKMHPGD | |
| SCHEMBL4442412 | 0.79 | SLC1A2 (0.54) | ALDH1A1MAPTHPGDALOX15KMT2A | |
| SCHEMBL7566579 | 0.78 | TTR (0.51) | MEN1ALDH1A1MAPTPKMHPGD | |
| SCHEMBL27568636 | 0.73 | CES2 (0.53) | KDM4EMEN1ALDH1A1EGFRTP53 | |
| SCHEMBL8232959 | 0.73 | OPRD1 (0.41) | KDM4EMEN1ALDH1A1EGFRTP53 | |
| SCHEMBL17047324 | 0.73 | ALDH1A1 (0.54) | ALDH1A1PIN1NPC1RAB9AHDAC3 | |
| SCHEMBL10362855 | 0.72 | HDAC8 (0.64) | KDM4EALOX15HSD17B10DEGS1CES2 | |
| SCHEMBL9595514 | 0.71 | PIN1 (0.49) | KDM4EMEN1ALDH1A1EGFRTP53 | |
| SCHEMBL7477122 | 0.71 | NPC1 (0.56) | KDM4EMEN1ALDH1A1KMT2APIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239179-B1 | SCHIZOPHRENIA, ALZHEIMER*S DISEASE, PARKINSON*S DISEASE, OBSESSIVE COMPULSIVE DISORDER, DRUG ABUSE, AND ANTIDEPRESSANTS; PSYCHOLOGICAL AND NERVOUS SYSTEM DISORDERS | NEUROGEN CORPORATION | 2001-05-29 | — | — | US | disclosed |
| US-6025493-A | FOR TREATMENT OF PSYCHOLOGICAL DISORDERS, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, NERVOUS SYSTEM DISORDERS | NEUROGEN CORPORATION (US) | 2000-02-15 | — | — | US | disclosed |
| US-5883257-A | NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0888320-A1 | NOVEL N-AMINOALKYL-2-ANTHRACENECARBOXAMIDES; NEW DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-01-07 | — | — | EP | disclosed |
| US-5703235-A | TREATMENT OF SCHIZOPHRENIA, DEPRESSION, ALZHEIMER*S DISEASE, PARKINSON*S DISEASE, DRUG ABUSE AND OBSESSIVE COMPULSIVE DISORDERS | NEUROGEN CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |
| US-5703235-A | TREATMENT OF SCHIZOPHRENIA, DEPRESSION, ALZHEIMER*S DISEASE, PARKINSON*S DISEASE, DRUG ABUSE AND OBSESSIVE COMPULSIVE DISORDERS | NEUROGEN CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |
| WO-1997034884-A1 | NOVEL N-AMINOALKYL-2-ANTHRACENECARBOXAMIDES; NEW DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1997-09-25 | — | — | WO | disclosed |