Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.61 |
| ▸ | RHEB | Q15382 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5950358 | 0.87 | SLC6A2 (0.50) | CXCL8SLC6A2SLC6A4SLC6A3CHRM1 | |
| SCHEMBL6961972 | 0.84 | CHRM1 (0.68) | CXCL8SLC6A2SLC6A4SLC6A3CHRM1 | |
| Ethylene Glycol SCHEMBL3365161 | 0.83 | CXCL8 (0.56) | CXCL8SLC6A2SLC6A4SLC6A3RHEB | |
| SCHEMBL11122864 | 0.81 | SLC6A2 (0.50) | CXCL8SLC6A2SLC6A4SLC6A3RHEB | |
| SCHEMBL7769553 | 0.80 | SLC6A2 (0.61) | CXCL8SLC6A2SLC6A4SLC6A3RHEB | |
| SCHEMBL9705386 | 0.80 | SLC6A2 (0.61) | CXCL8SLC6A2SLC6A4SLC6A3RHEB | |
| SCHEMBL112757 | 0.80 | SLC6A2 (0.61) | CXCL8SLC6A2SLC6A4SLC6A3CHRM1 | |
| SCHEMBL11430105 | 0.80 | SLC6A2 (0.66) | CXCL8SLC6A2SLC6A4SLC6A3CHRM1 | |
| SCHEMBL1436765 | 0.80 | HPGD (0.59) | CXCL8SLC6A2SLC6A4SLC6A3RHEB | |
| SCHEMBL11095518 | 0.78 | HPGD (0.55) | CXCL8SLC6A2SLC6A4SLC6A3RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1216052-C | Anti-neurodegeneratively active 10-aminoaliphatyl-dibenz (b,f) oxepines | NAVARTIS AG (CH) | 2005-08-24 | — | — | CN | disclosed |
| EP-0726265-B1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | NOVARTIS AG (CH) | 2001-07-25 | — | — | EP | disclosed |
| US-5780501-A | ADMINISTERING TO A MAMMAL | NOVARTIS CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| US-5780500-A | Anti-neurodegeneratively active 10-aminoaliphatyl-dibenzi b,f! oxepines | NOVARTIS CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| CN-1137039-A | Anti-neurodegeneratively active 10-aminoaliphatyl-dibenz (b,f) oxepines | CIBA GEIGY AG (CH) | 1996-12-04 | — | — | CN | disclosed |
| EP-0726265-A1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | CIBA-GEIGY AG (CH) | 1996-08-14 | — | — | EP | disclosed |