SCHEMBL9705386

SCHEMBL9705386

[CH2]Cc1ccccc1Oc1ccccc1Cl

nearest known ligand 0.61

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 8/20 0.61
SLC6A3 Q01959 8/20 0.61
SLC6A4 P31645 7/20 0.61
CXCL8 P10145 1/20 0.59
HPGD P15428 1/20 0.44
CHRM1 P11229 1/20 0.44
CAMK2A Q9UQM7 2/20 0.43
HTT P42858 2/20 0.42
ALDH1A1 P00352 1/20 0.42
TP53 P04637 1/20 0.40
IDO1 P14902 1/20 0.39
RHEB Q15382 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11430105 0.80 SLC6A2 (0.66) SLC6A2SLC6A3SLC6A4CXCL8HPGD
SCHEMBL7769553 0.80 SLC6A2 (0.61) SLC6A2SLC6A3SLC6A4CXCL8HPGD
SCHEMBL7765702 0.80 CXCL8 (0.64) SLC6A2SLC6A3SLC6A4CXCL8HPGD
SCHEMBL112757 0.80 SLC6A2 (0.61) SLC6A2SLC6A3SLC6A4CXCL8HPGD
SCHEMBL1436765 0.80 HPGD (0.59) SLC6A2SLC6A3SLC6A4CXCL8HPGD
Bromide SCHEMBL28304801 0.78 HPGD (0.57) SLC6A2SLC6A3SLC6A4CXCL8HPGD
SCHEMBL9704852 0.77 SLC6A4 (0.63) SLC6A2SLC6A3SLC6A4HTT
SCHEMBL19926361 0.76 SLC6A4 (0.60) SLC6A2SLC6A3SLC6A4CXCL8HPGD
SCHEMBL7770746 0.76 SLC6A4 (0.56) SLC6A2SLC6A3SLC6A4CXCL8HPGD
SCHEMBL128364 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5159117-A Reacting ketone or aldehyde with nitrites in presence of acid catalyst BASF AKTIENGESELLSCHAFT (DE) 1992-10-27 US disclosed