Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7769544 | 0.86 | TRPA1 (0.41) | TRPA1LMNAHTR2AHTR2CCYP19A1 | |
| SCHEMBL5952981 | 0.84 | TRPA1 (0.39) | TRPA1LMNAHTR2AHTR2CCYP19A1 | |
| SCHEMBL5953534 | 0.84 | HTR2A (0.44) | TRPA1LMNAHTR2AHTR2CCYP19A1 | |
| SCHEMBL6685325 | 0.79 | DRD2 (0.44) | TRPA1LMNAMAPTTDP1KDM4E | |
| SCHEMBL5953348 | 0.78 | DRD2 (0.48) | MAPTTDP1KDM4EDRD2DRD4 | |
| SCHEMBL7770756 | 0.78 | LMNA (0.60) | TRPA1LMNACYP19A1HDAC3TUBB4A | |
| SCHEMBL5953775 | 0.78 | PYCR1 (0.45) | TRPA1LMNAHTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL9630555 | 0.76 | MEN1 (0.42) | MAPTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL7770761 | 0.75 | LMNA (0.44) | TRPA1LMNACYP19A1HDAC3TUBB4A | |
| Metoxepin SCHEMBL2109740 | 0.72 | DRD2 (0.70) | HTR2AHTR2CMAPTTDP1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726265-B1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | NOVARTIS AG (CH) | 2001-07-25 | — | — | EP | disclosed |
| EP-0726265-A1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | CIBA-GEIGY AG (CH) | 1996-08-14 | — | — | EP | disclosed |