Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7766827 | 0.96 | CYP2C19 (0.39) | CYP2C19GBA1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7764873 | 0.91 | CYP2C19 (0.41) | CYP2C19GBA1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7766815 | 0.83 | CRBN (0.43) | CYP2C19CYP3A4SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7762185 | 0.74 | CRBN (0.42) | CYP2C19GBA1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7766697 | 0.73 | EHMT2 (0.38) | CYP2C19GBA1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL28965534 | 0.72 | CYP2C19 (0.57) | CYP2C19GBA1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7764999 | 0.71 | ALDH1A1 (0.37) | CYP2C19CYP1A2CYP2C9SMN1; SMN2ALDH1A1 | |
| SCHEMBL6306047 | 0.71 | CYP2C19 (0.59) | CYP2C19GBA1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7153568 | 0.70 | CYP1A2 (0.49) | CYP1A2ALDH1A1GRM2 | |
| SCHEMBL10854504 | 0.70 | HTT (0.41) | CYP2C19GBA1CYP1A2CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639566-B1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5461158-A | Immunodeficiency and autoimmune diseases | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0639566-A1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-02-22 | — | — | EP | disclosed |