Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | F13A1 | P00488 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5080048 | 0.82 | TOP2A (0.43) | TOP2ASLC22A12HDAC6F13A1TGM2 | |
| SCHEMBL27478753 | 0.82 | TOP2A (0.43) | TOP2ASLC22A12HDAC6F13A1TGM2 | |
| SCHEMBL6938598 | 0.76 | L3MBTL1 (0.39) | KMT2AMAPTSMN1; SMN2NPC1POLB | |
| SCHEMBL27510144 | 0.74 | MEN1 (0.45) | TOP2ASLC22A12HDAC6HPGDMEN1 | |
| SCHEMBL1457083 | 0.73 | — | — | |
| SCHEMBL1413119 | 0.71 | F13A1 (0.46) | TOP2ASLC22A12HDAC6F13A1TGM2 | |
| SCHEMBL9320443 | 0.70 | MAPT (0.41) | F13A1TGM2MEN1KMT2AMAPT | |
| SCHEMBL10339863 | 0.69 | HPGD (0.46) | TOP2ASLC22A12HDAC6F13A1TGM2 | |
| SCHEMBL2019602 | 0.69 | — | — | |
| SCHEMBL9322124 | 0.69 | DDX3X (0.47) | HDAC6HPGDMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100484-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000003704-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-27 | — | — | WO | disclosed |