Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 4/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4212043 | 0.90 | MAOB (0.58) | SMPD1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL2199661 | 0.88 | NPC1 (0.53) | SMPD1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL29032389 | 0.88 | SMPD1 (0.53) | SMPD1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL27571102 | 0.88 | MAOB (0.64) | HTTFFAR1MAOBMAOA | |
| SCHEMBL14893940 | 0.87 | MAOB (0.63) | SMPD1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL7907439 | 0.85 | MAOB (0.56) | SMPD1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL28396682 | 0.84 | MAPT (0.52) | SMPD1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL8425312 | 0.83 | RAB9A (0.65) | SMPD1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL8973177 | 0.83 | KDM4E (0.53) | RAB9APOLBMAPTKDM4ECYP1A2 | |
| SCHEMBL22873361 | 0.82 | MAOB (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825178-B1 | Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or in diagnostic agents and drugs containing them | HOECHST AG (DE) | 2001-06-20 | — | — | EP | disclosed |
| EP-0825178-A1 | Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or in diagnostic agents and drugs containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-25 | — | — | EP | disclosed |