Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.58 |
| ▸ | MAOA | P21397 | 4/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.57 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15615390 | 0.91 | MAOB (0.58) | MAOBMAOACA12CA1CA2 | |
| SCHEMBL7765941 | 0.90 | SMPD1 (0.56) | MAOBMAOANPC1RAB9AALDH1A1 | |
| SCHEMBL7911129 | 0.89 | MAOB (0.75) | MAOBMAOACA12CA1CA2 | |
| SCHEMBL7900785 | 0.89 | MAOB (0.75) | MAOBMAOACA12CA1CA2 | |
| SCHEMBL629952 | 0.88 | MAOB (0.74) | MAOBMAOACA12CA1CA2 | |
| SCHEMBL29032389 | 0.87 | SMPD1 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL31166914 | 0.87 | MAOB (0.76) | MAOBMAOANPC1RAB9AALDH1A1 | |
| SCHEMBL3540404 | 0.87 | MAOB (0.76) | MAOBMAOANPC1RAB9AALDH1A1 | |
| SCHEMBL7911261 | 0.86 | MAOB (0.56) | MAOBMAOACA12CA1CA2 | |
| SCHEMBL7911046 | 0.86 | MAOB (0.57) | MAOBMAOAMAPTHTTAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116438174-A | Compounds and their use as MIF inhibitors | 南京艾美斐生物医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| US-20090062322-A1 | Novel Tricyclic Spiropiperidines or Spiropyrrolidines | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | US | disclosed |
| US-7449475-B2 | Tricyclic spiropiperidines or spiropyrrolidines | ASTRAZENECA AB (SE) | 2008-11-11 | — | — | US | disclosed |
| EP-1521757-B1 | TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | EP | disclosed |
| US-20070203230-A1 | Novel Tricyclic Spiroderivatives as Modulators of Chemokine Receptor Activity | ASTRAZENECA AB | 2007-08-30 | — | — | US | disclosed |
| US-20070203229-A1 | Novel Tricyclic Spiroderivatives as Modulators of Chemokine Receptor Activity | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | US | disclosed |
| US-20070021498-A1 | Novel tricyclic spiroderivatives as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2007-01-25 | — | — | US | disclosed |
| EP-1678156-A1 | NOVEL TRICYCLIC SPIRODERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2006-07-12 | — | — | EP | disclosed |
| US-20050245741-A1 | Novel tricyclic spiropiperidines or spiropyrrolidines | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
| WO-2005037814-A1 | NOVEL TRICYCLIC SPIRODERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2005-04-28 | — | — | WO | disclosed |
| EP-1521757-A1 | NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | AstraZeneca AB (SE) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004005295-A1 | NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |
| US-6211234-B1 | BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID | RHONE-POULENC RORER LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| EP-0728128-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013262-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062322-A1 | Novel Tricyclic Spiropiperidines or Spiropyrrolidines | REN, TACR1, AGTR1 | MAOB 1938/4885MAOA 3038/4885CA12 4572/4885 |
| US-20070203230-A1 | Novel Tricyclic Spiroderivatives as Modulators of Chemokine Receptor Activity | CXCR1, CXCR2, CXCR4 | MAOB 3191/4885MAOA 4309/4885CA12 4406/4885 |
| US-20070203229-A1 | Novel Tricyclic Spiroderivatives as Modulators of Chemokine Receptor Activity | CXCR1, CXCR2, CXCR4 | MAOB 3191/4885MAOA 4309/4885CA12 4406/4885 |
| US-20050245741-A1 | Novel tricyclic spiropiperidines or spiropyrrolidines | REN, TACR1, AGTR1 | MAOB 1908/4885MAOA 3064/4885CA12 4571/4885 |
| US-20070021498-A1 | Novel tricyclic spiroderivatives as modulators of chemokine receptor activity | CXCR1, CXCR2, CXCR4 | MAOB 3287/4885MAOA 4352/4885CA12 4497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.