Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | OTC | P00480 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY4R | P50391 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL2485033 | 0.87 | OTC (0.43) | SLC1A5KMT2AALDH1A1MAPTOTC | |
| Arginine SCHEMBL1287134 | 0.84 | OTC (0.43) | CASRKMT2AOTC | |
| Arginine SCHEMBL4606882 | 0.84 | F10 (0.44) | KMT2AOTCPRSS1TMPRSS15F2 | |
| Arginine SCHEMBL4606883 | 0.84 | F10 (0.44) | KMT2AOTCPRSS1TMPRSS15F2 | |
| Arginine SCHEMBL16879777 | 0.84 | KIF11 (0.47) | KMT2AOTCNPY1RNPY4R | |
| Arginine SCHEMBL12006798 | 0.84 | OTC (0.43) | CASRKMT2AOTC | |
| SCHEMBL2246952 | 0.83 | NPY4R (0.39) | GAASLC1A5KMT2AALDH1A1MAPT | |
| Arginine SCHEMBL28911625 | 0.83 | OTC (0.43) | CASRKMT2AOTC | |
| SCHEMBL28911603 | 0.82 | NPY4R (0.38) | GAASLC1A5KMT2AALDH1A1MAPT | |
| Dl-Phenylalanine SCHEMBL27756967 | 0.82 | SLC7A5 (0.49) | NPY1RNPY4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1106701-A1 | MONOCLONAL ANTIBODY AGAINST CANINE TRYPSIN | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 2001-06-13 | — | — | EP | disclosed |