SCHEMBL7766527

SCHEMBL7766527

CC(C)(C)OC(=O)C(N)c1cccc(C(=O)NC2CCN(Cc3ccccc3)CC2)c1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.59
SIGMAR1 Q99720 3/20 0.59
MEN1 O00255 2/20 0.57
MAOB P27338 1/20 0.56
MCHR1 Q99705 2/20 0.56
TMEM97 Q5BJF2 3/20 0.55
SLC6A12 P48065 3/20 0.55
DRD4 P21917 2/20 0.55
SLC6A13 Q9NSD5 2/20 0.55
DRD2 P14416 1/20 0.53
KCNH2 Q12809 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
TSHR P16473 1/20 0.52
MAPK1 P28482 1/20 0.52
CYP2C19 P33261 1/20 0.52
RAB9A P51151 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7771602 0.81 SMYD3 (0.42) RAB9A
SCHEMBL7766531 0.80 KMT2A (0.62) KMT2ASIGMAR1MEN1MAOBMCHR1
SCHEMBL694949 0.76 SIGMAR1 (0.82) KMT2ASIGMAR1MEN1MCHR1TMEM97
SCHEMBL8706202 0.76 DRD4 (0.87) KMT2ASIGMAR1MEN1MCHR1TMEM97
SCHEMBL915402 0.76 KMT2A (0.65) KMT2ASIGMAR1MEN1MAOBMCHR1
SCHEMBL28758216 0.76 KDM1A (0.56) KMT2ASIGMAR1MEN1MAOBMCHR1
SCHEMBL31736417 0.75 MCHR1 (0.77) KMT2ASIGMAR1MEN1MAOBMCHR1
SCHEMBL27448907 0.75 KMT2A (1.00) KMT2ASIGMAR1MEN1MCHR1TMEM97
SCHEMBL7218037 0.75 SIGMAR1 (1.00) KMT2ASIGMAR1MEN1MCHR1TMEM97
SCHEMBL184424 0.74 ANPEP (0.51) KMT2AMEN1CYP1A2CYP3A4MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115731-A2 NOVEL PYRANOSES Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2001-07-18 EP disclosed
WO-2000014097-A2 NOVEL PYRANOSES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-03-16 WO disclosed