SCHEMBL7766531

SCHEMBL7766531

CC(C)(C)OC(=O)NCc1cccc(C(=O)NC2CCN(Cc3ccccc3)CC2)c1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.62
SIGMAR1 Q99720 3/20 0.62
TMEM97 Q5BJF2 3/20 0.60
MEN1 O00255 2/20 0.60
MAOB P27338 1/20 0.59
MCHR1 Q99705 2/20 0.58
DRD4 P21917 3/20 0.58
SLC6A12 P48065 3/20 0.58
SLC6A13 Q9NSD5 2/20 0.58
DRD2 P14416 1/20 0.56
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54
TSHR P16473 1/20 0.54
MAPK1 P28482 1/20 0.54
CYP2C19 P33261 1/20 0.54
RAB9A P51151 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7766536 0.88 DRD4 (0.69) KMT2ASIGMAR1MEN1MAOBMCHR1
SCHEMBL5564933 0.88 SMYD3 (0.55) RAB9A
SCHEMBL28758216 0.84 KDM1A (0.56) KMT2ASIGMAR1TMEM97MEN1MAOB
SCHEMBL7771603 0.83 ROCK2 (0.53)
SCHEMBL915402 0.82 KMT2A (0.65) KMT2ASIGMAR1MEN1MAOBMCHR1
SCHEMBL26813993 0.82 DRD4 (0.51) KMT2ASIGMAR1TMEM97MEN1MAOB
SCHEMBL4730142 0.81 SIGMAR1 (0.62) KMT2ASIGMAR1MEN1DRD4
SCHEMBL7766527 0.80 KMT2A (0.59) KMT2ASIGMAR1TMEM97MEN1MAOB
SCHEMBL3593211 0.80 KDM4E (0.58) KMT2ASIGMAR1MEN1MAOBMCHR1
SCHEMBL9542849 0.79 ROCK2 (0.49) KMT2ADRD4DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115731-A2 NOVEL PYRANOSES Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2001-07-18 EP disclosed
WO-2000014097-A2 NOVEL PYRANOSES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-03-16 WO disclosed