Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767444 | 1.00 | HTT (0.46) | HTTGAACA1CA2TSHR | |
| SCHEMBL7764872 | 0.83 | CYP3A4 (0.47) | HTTGAAALDH1A1HPGDRAB9A | |
| SCHEMBL7764876 | 0.83 | CYP3A4 (0.47) | HTTGAAALDH1A1HPGDRAB9A | |
| SCHEMBL7764925 | 0.81 | LTA4H (0.45) | HTTTSHRALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7764929 | 0.81 | LTA4H (0.45) | HTTTSHRALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2215429 | 0.74 | L3MBTL1 (0.60) | HTTCA1CA2TSHRALDH1A1 | |
| SCHEMBL2215434 | 0.74 | L3MBTL1 (0.60) | HTTCA1CA2TSHRALDH1A1 | |
| SCHEMBL7764897 | 0.72 | PPID (0.42) | TSHRALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5697514 | 0.70 | LOXL2 (0.54) | CA1CA2ALDH1A1HPGDRAB9A | |
| SCHEMBL1928912 | 0.70 | TSHR (0.67) | CA1CA2TSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639566-B1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5461158-A | Immunodeficiency and autoimmune diseases | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0639566-A1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-02-22 | — | — | EP | disclosed |