Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.36 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343148 | 0.83 | SIRT6 (0.33) | SIRT6P4HTMP4HA1MIFKDM4E | |
| Potassium Ion SCHEMBL11741297 | 0.81 | POLB (0.47) | KDM4EALDH1A1HPGDPOLBKMT2A | |
| Lithium Ion SCHEMBL6078511 | 0.81 | SIRT6 (0.61) | SIRT6P4HTMALDH1A1NAPRTCA2 | |
| SCHEMBL17820695 | 0.76 | KDM4E (0.33) | SIRT6P4HTMKDM4EALDH1A1HCAR2 | |
| Pyrazinoic Acid SCHEMBL28360997 | 0.72 | KDM4E (0.61) | KDM4EHCAR2NAPRTADORA3TSHR | |
| Pyrazinoic Acid SCHEMBL970038 | 0.72 | KDM4E (0.61) | KDM4EHCAR2NAPRTADORA3TSHR | |
| Pyrazinoic Acid SCHEMBL8626539 | 0.72 | KDM4E (0.61) | KDM4EHCAR2NAPRTADORA3TSHR | |
| Pyrazinoic Acid SCHEMBL11128823 | 0.72 | KDM4E (0.61) | KDM4EHCAR2NAPRTADORA3TSHR | |
| Pyrazinoic Acid SCHEMBL2158528 | 0.72 | KDM4E (0.61) | KDM4EHCAR2NAPRTADORA3TSHR | |
| SCHEMBL22346487 | 0.72 | SIRT6 (0.35) | SIRT6P4HTMKDM4EMAPK1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624813-B1 | Light valve suspensions and films containing UV absorbers and light valves containing the same | RESEARCH FRONTIERS INC (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-0669010-B1 | LIGHT MODULATING FILM OF IMPROVED CLARITY FOR A LIGHT VALVE | RESEARCH FRONTIERS INC (US) | 2000-06-21 | — | — | EP | disclosed |
| EP-0989445-A2 | A liquid suspension for a light valve | RESEARCH FRONTIERS INCORPORATED (US) | 2000-03-29 | — | — | EP | disclosed |
| US-5467217-A | Light valve suspensions and films containing UV absorbers and light valves containing the same | RESEARCH FRONTIERS INCORPORATED (US) | 1995-11-14 | — | — | US | disclosed |
| US-5463492-A | Light modulating film of improved clarity for a light valve | RESEARCH FRONTIERS INCORPORATED (US) | 1995-10-31 | — | — | US | disclosed |
| US-5463491-A | Light valve employing a film comprising an encapsulated liquid suspension, and method of making such film | RESEARCH FRONTIERS INCORPORATED (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0669010-A4 | — | — | 1995-09-27 | — | — | EP | disclosed |
| EP-0669010-A1 | LIGHT MODULATING FILM OF IMPROVED CLARITY FOR A LIGHT VALVE | RESEARCH FRONTIERS INCORPORATED (US) | 1995-08-30 | — | — | EP | disclosed |
| EP-0624813-A1 | Light valve suspensions and films containing UV absorbers and light valves containing the same | RESEARCH FRONTIERS INCORPORATED (US) | 1994-11-17 | — | — | EP | disclosed |
| WO-1994011772-A1 | LIGHT MODULATING FILM OF IMPROVED CLARITY FOR A LIGHT VALVE | RESEARCH FRONTIERS INCORPORATED (US) | 1994-05-26 | — | — | WO | disclosed |