Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 9/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901490 | 0.85 | CYP2C9 (0.44) | CYP2C9TSHRAPPMAPTHTT | |
| SCHEMBL29752747 | 0.84 | TSHR (0.61) | CYP2C9TSHRMAPTHTTSMN1; SMN2 | |
| SCHEMBL1586597 | 0.79 | AR (0.53) | CYP2C9TSHRAPPMAPTHTT | |
| SCHEMBL1586593 | 0.79 | AR (0.53) | CYP2C9TSHRAPPMAPTHTT | |
| Hydrochloric Acid SCHEMBL8899736 | 0.79 | APP (0.48) | CYP2C9TSHRAPPMAPTSMN1; SMN2 | |
| SCHEMBL978754 | 0.78 | LMNA (0.55) | TSHRMAPTHTTSMN1; SMN2LMNA | |
| SCHEMBL668899 | 0.76 | KMT2A (0.48) | CYP2C9TSHRMAPTHTTSMN1; SMN2 | |
| SCHEMBL1698976 | 0.75 | ALDH1A1 (0.43) | CYP2C9TSHRAPPMAPTSMN1; SMN2 | |
| SCHEMBL4517217 | 0.73 | LMNA (0.64) | APPMAPTLMNAPOLBNPSR1 | |
| SCHEMBL27452883 | 0.71 | MAPT (0.57) | TSHRMAPTSMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| US-5830920-A | PREVENTION GROWTH OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |