Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.52 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7768982 | 0.95 | PLA2G4B (0.55) | SRD5A2NR1H4PLA2G4BPKMMAPK1 | |
| SCHEMBL9741504 | 0.91 | PLA2G4B (0.55) | SRD5A2NR1H4PLA2G4BPKMMAPK1 | |
| SCHEMBL7768531 | 0.88 | PKM (0.58) | SRD5A2NR1H4PLA2G4BPKMMAPK1 | |
| SCHEMBL13309703 | 0.83 | RARB (0.61) | RARBSRD5A2NR1H4PLA2G4BPKM | |
| SCHEMBL14789253 | 0.82 | PLA2G4B (0.57) | RARBSRD5A2NR1H4PLA2G4BPKM | |
| SCHEMBL9741323 | 0.80 | PLA2G4B (0.71) | NR1H4PLA2G4BPKMMAPK1LMNA | |
| SCHEMBL8569877 | 0.78 | PKM (0.78) | RARBSRD5A2PLA2G4BPKMMAPK1 | |
| SCHEMBL7699688 | 0.78 | MAPT (0.60) | RARBSRD5A2NR1H4PLA2G4BMAPK1 | |
| SCHEMBL7699686 | 0.78 | MAPT (0.60) | RARBSRD5A2NR1H4PLA2G4BMAPK1 | |
| SCHEMBL8652183 | 0.77 | LMNA (0.63) | RARBSRD5A2NR1H4PLA2G4BPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| US-5830920-A | PREVENTION GROWTH OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |