Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7768982 | 0.92 | PLA2G4B (0.55) | PKMPLA2G4BMAPK1NR4A2POLB | |
| SCHEMBL9741504 | 0.92 | PLA2G4B (0.55) | PKMPLA2G4BMAPK1NR4A2POLB | |
| SCHEMBL9741323 | 0.88 | PLA2G4B (0.71) | PKMPLA2G4BMAPK1NR4A2POLB | |
| SCHEMBL7768977 | 0.88 | RARB (0.54) | PKMPLA2G4BMAPK1NR4A2POLB | |
| SCHEMBL8480906 | 0.85 | PLA2G4B (0.55) | PKMPLA2G4BMAPK1NR4A2POLB | |
| SCHEMBL8652183 | 0.85 | LMNA (0.63) | PKMPLA2G4BMAPK1NR4A2POLB | |
| SCHEMBL24198673 | 0.83 | PLA2G4B (0.61) | PKMPLA2G4BMAPK1NR4A2POLB | |
| SCHEMBL17908101 | 0.83 | PLA2G4B (0.61) | PKMPLA2G4BMAPK1NR4A2POLB | |
| SCHEMBL17908021 | 0.83 | PLA2G4B (0.61) | PKMPLA2G4BMAPK1NR4A2POLB | |
| SCHEMBL4366529 | 0.82 | PKM (0.56) | PKMPLA2G4BMAPK1NR4A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| US-5830920-A | PREVENTION GROWTH OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |