Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RARA | P10276 | 5/20 | 0.40 |
| ▸ | RARB | P10826 | 5/20 | 0.40 |
| ▸ | RARG | P13631 | 5/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763882 | 0.88 | ALDH1A1 (0.41) | ALDH1A1HPGD | |
| SCHEMBL7771473 | 0.85 | SRD5A2 (0.48) | ALDH1A1RARBHPGD | |
| SCHEMBL7768494 | 0.82 | RXRA (0.44) | ALDH1A1HPGD | |
| SCHEMBL7766960 | 0.81 | PKM (0.47) | RARBCYP26A1CYP26B1 | |
| SCHEMBL7763872 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1HPGD | |
| SCHEMBL7767571 | 0.78 | SRD5A2 (0.51) | RARB | |
| SCHEMBL7766997 | 0.78 | SRD5A2 (0.51) | RARB | |
| SCHEMBL7768507 | 0.77 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGD | |
| SCHEMBL7767015 | 0.76 | ALDH1A1 (0.38) | ALDH1A1CYP26A1CYP26B1HPGD | |
| SCHEMBL7767603 | 0.76 | ALDH1A1 (0.45) | KDM4EALDH1A1MRGPRX4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| US-5830920-A | PREVENTION GROWTH OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |