SCHEMBL7769124

SCHEMBL7769124

Nc1cc(S(=O)(=O)F)ccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.50
NPSR1 Q6W5P4 1/20 0.50
CA12 O43570 4/20 0.47
CA1 P00915 4/20 0.47
CA2 P00918 4/20 0.47
CA9 Q16790 4/20 0.47
CA7 P43166 3/20 0.47
CA14 Q9ULX7 3/20 0.47
CA4 P22748 2/20 0.47
CA6 P23280 2/20 0.47
CA5A P35218 2/20 0.47
CA5B Q9Y2D0 2/20 0.47
TSHR P16473 3/20 0.46
TP53 P04637 2/20 0.46
PKM P14618 3/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
LMNA P02545 1/20 0.41
ALDH1A1 P00352 4/20 0.41
GAA P10253 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5738131 0.83 CA1 (0.68) MAPTCA12CA1CA2CA9
SCHEMBL3077407 0.83 MAPT (0.57) MAPTNPSR1CA12CA1CA2
SCHEMBL30932826 0.83 MAPT (0.57) MAPTNPSR1CA12CA1CA2
SCHEMBL1186046 0.81 CA2 (0.70) MAPTNPSR1CA12CA1CA2
SCHEMBL27538809 0.81 MAPT (0.51) MAPTNPSR1CA12CA1CA2
SCHEMBL10391068 0.80 ALDH1A1 (0.61) MAPTCA12CA1CA2CA9
SCHEMBL11153639 0.80 APEX1 (0.48) MAPTCA12CA1CA2CA9
SCHEMBL341943 0.79 ALDH1A1 (0.62) MAPTNPSR1CA12CA1CA2
SCHEMBL1370002 0.79 LMNA (0.55) MAPTNPSR1CA12CA1CA2
SCHEMBL27781331 0.79 MAPT (0.50) MAPTNPSR1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0921790-A4 SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE UNIV TEXAS (US) 2000-11-02 EP claimed
EP-0921790-A1 SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE The Board of Regents, The University of Texas System (US) 1999-06-16 EP claimed
US-5798392-A IRREVERSIBLE ACETYLCHOLINESTERASE INHIBITORS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 1998-08-25 US claimed
WO-1998008497-A1 SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 1998-03-05 WO claimed
EP-0740690-B1 MONOAZO DYES CONTAINING A FLUOROSULPHONYL GROUP AND USE THEREOF SYNGENTA LTD (GB) 2001-06-20 EP disclosed
EP-0921790-A4 SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE UNIV TEXAS (US) 2000-11-02 EP disclosed
EP-0921790-A1 SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE The Board of Regents, The University of Texas System (US) 1999-06-16 EP disclosed
US-5798392-A IRREVERSIBLE ACETYLCHOLINESTERASE INHIBITORS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 1998-08-25 US disclosed
US-5739299-A GOOD WET FASTNESS AND LIGHT FASTNESS PROPERTIES ZENECA LIMITED (GB) 1998-04-14 US disclosed
WO-1998008497-A1 SULFONYL FLUORIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 1998-03-05 WO disclosed
EP-0740690-A1 MONOAZO DYES CONTAINING A FLUOROSULPHONYL GROUP AND USE THEREOF ZENECA LIMITED (GB) 1996-11-06 EP disclosed
WO-1995020014-A1 MONOAZO DYES CONTAINING A FLUOROSULPHONYL GROUP AND USE THEREOF ZENECA LIMITED (GB) 1995-07-27 WO disclosed
EP-0250201-A2 Photographic silver halide element and process EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1987-12-23 EP disclosed