Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7765680 | 0.92 | THRB (0.63) | KMT2ANR1H4SMPD1THRBKAT6A | |
| SCHEMBL27913517 | 0.86 | KMT2A (0.78) | KMT2ANR1H4SMN1; SMN2MAPTSMPD1 | |
| SCHEMBL5250834 | 0.86 | HPGD (0.56) | KMT2ANR1H4SMN1; SMN2MAPTNPC1 | |
| SCHEMBL1436064 | 0.85 | KMT2A (0.76) | KMT2ANR1H4SMN1; SMN2MAPTSMPD1 | |
| SCHEMBL609434 | 0.85 | KMT2A (1.00) | KMT2ANR1H4SMN1; SMN2SMPD1NPC1 | |
| SCHEMBL11052390 | 0.83 | KMT2A (0.73) | KMT2ANR1H4SMN1; SMN2MAPTSMPD1 | |
| SCHEMBL201524 | 0.83 | KMT2A (0.73) | KMT2ANR1H4SMN1; SMN2SMPD1NPC1 | |
| SCHEMBL27812355 | 0.83 | KMT2A (0.73) | KMT2ANR1H4SMN1; SMN2MAPTSMPD1 | |
| SCHEMBL5200730 | 0.83 | KMT2A (0.73) | KMT2ANR1H4SMN1; SMN2MAPTSMPD1 | |
| SCHEMBL11696519 | 0.82 | KMT2A (0.77) | KMT2ANR1H4SMN1; SMN2MAPTSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |