Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382433 | 0.81 | KDM4E (1.00) | KDM4EHPGDALDH1A1LMNAL3MBTL1 | |
| SCHEMBL11516210 | 0.79 | MAPK13 (0.53) | KDM4EHPGDALDH1A1LMNAL3MBTL1 | |
| SCHEMBL5850257 | 0.76 | KDM4E (0.68) | KDM4EHPGDALDH1A1LMNAL3MBTL1 | |
| SCHEMBL1980159 | 0.73 | XDH (0.50) | KDM4EHPGDALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7769428 | 0.73 | KDM4E (0.48) | KDM4EHPGDALDH1A1LMNAL3MBTL1 | |
| SCHEMBL16868394 | 0.73 | KDM4E (0.48) | KDM4EHPGDALDH1A1LMNAL3MBTL1 | |
| SCHEMBL23758282 | 0.73 | GAA (0.58) | KDM4EHPGDALDH1A1SMN1; SMN2MAPK13 | |
| SCHEMBL8313104 | 0.73 | MEN1 (0.47) | KDM4EHPGDALDH1A1LMNAL3MBTL1 | |
| SCHEMBL4111920 | 0.70 | KDM4E (0.69) | KDM4EHPGDALDH1A1LMNAL3MBTL1 | |
| SCHEMBL19116734 | 0.70 | L3MBTL1 (0.61) | KDM4EHPGDALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112072-A2 | METHIMAZOLE DERIVATIVES AND TAUTOMERIC CYCLIC THIONES TO TREAT AUTOIMMUNE DISEASES | Sentron Medical, Inc. (US) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000012175-A2 | METHIMAZOLE DERIVATIVES AND TAUTOMERIC CYCLIC THIONES TO TREAT AUTOIMMUNE DISEASES | SENTRON MEDICAL, INC. (US) | 2000-03-09 | — | — | WO | disclosed |