Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116552 | 0.80 | CYP11B1 (0.54) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5850257 | 0.79 | KDM4E (0.68) | KDM4EHPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL1172425 | 0.78 | KDM4E (0.60) | KDM4EHPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL11516210 | 0.78 | MAPK13 (0.53) | KDM4EHPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL16868394 | 0.76 | KDM4E (0.48) | KDM4EHPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL1980159 | 0.76 | XDH (0.50) | KDM4EHPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL7769423 | 0.73 | KDM4E (0.69) | KDM4EHPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL4111920 | 0.73 | KDM4E (0.69) | KDM4EHPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL19116734 | 0.73 | L3MBTL1 (0.61) | KDM4EHPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL23758282 | 0.72 | GAA (0.58) | KDM4EHPGDSMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112072-A2 | METHIMAZOLE DERIVATIVES AND TAUTOMERIC CYCLIC THIONES TO TREAT AUTOIMMUNE DISEASES | Sentron Medical, Inc. (US) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000015768-A9 | IMMUNE ACTIVATION BY DOUBLE-STRANDED POLYNUCLEOTIDES | KOHN LEONARD D (US) | 2000-08-31 | — | — | WO | disclosed |
| WO-2000012175-A2 | METHIMAZOLE DERIVATIVES AND TAUTOMERIC CYCLIC THIONES TO TREAT AUTOIMMUNE DISEASES | SENTRON MEDICAL, INC. (US) | 2000-03-09 | — | — | WO | disclosed |