Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
| ▸ | RELA | Q04206 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7770728 | 0.85 | DRD2 (0.43) | MAPTDRD2DRD4TP53CYP1A2 | |
| SCHEMBL6685325 | 0.82 | DRD2 (0.44) | MAPTDRD2DRD4TP53CYP1A2 | |
| SCHEMBL5953744 | 0.79 | DRD2 (0.46) | MAPTDRD2DRD4TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL9056544 | 0.78 | DRD2 (0.46) | MAPTDRD2DRD4TP53CYP1A2 | |
| SCHEMBL4038906 | 0.75 | LMNA (0.71) | MAPTDRD2DRD4TP53CYP1A2 | |
| SCHEMBL5953640 | 0.75 | PYCR1 (0.45) | MAPTDRD2DRD4TP53CYP1A2 | |
| SCHEMBL7770745 | 0.72 | LMNA (0.46) | MAPTDRD2DRD4TP53CYP1A2 | |
| SCHEMBL9949394 | 0.72 | MAPT (0.48) | MAPTDRD2DRD4TP53CYP1A2 | |
| SCHEMBL1842504 | 0.71 | DRD2 (0.56) | MAPTDRD2DRD4TP53CYP1A2 | |
| SCHEMBL5953153 | 0.70 | DRD2 (0.52) | MAPTDRD2DRD4TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726265-B1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | NOVARTIS AG (CH) | 2001-07-25 | — | — | EP | disclosed |
| EP-0726265-A1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | CIBA-GEIGY AG (CH) | 1996-08-14 | — | — | EP | disclosed |