Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GYS1 | P13807 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | PTAFR | P25105 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7769952 | 1.00 | GYS1 (0.38) | GYS1MEN1KMT2AF10ADRB1 | |
| SCHEMBL7766546 | 0.89 | CYP3A4 (0.39) | MEN1KMT2AF10ADRB1ADRB3 | |
| SCHEMBL7766538 | 0.89 | CYP3A4 (0.39) | MEN1KMT2AF10ADRB1ADRB3 | |
| SCHEMBL7771600 | 0.87 | ADRB2 (0.41) | MEN1KMT2AADRB1ADRB3ADRB2 | |
| SCHEMBL7771601 | 0.87 | ADRB2 (0.41) | MEN1KMT2AADRB1ADRB3ADRB2 | |
| SCHEMBL7769942 | 0.84 | MEN1 (0.39) | MEN1KMT2AADRB1ADRB3ALDH1A1 | |
| SCHEMBL7769940 | 0.84 | MEN1 (0.39) | MEN1KMT2AADRB1ADRB3ALDH1A1 | |
| SCHEMBL7771595 | 0.81 | CA2 (0.50) | MEN1KMT2AADRB1ADRB3ADRB2 | |
| SCHEMBL4853590 | 0.81 | CA2 (0.50) | MEN1KMT2AADRB1ADRB3ADRB2 | |
| SCHEMBL7772401 | 0.81 | MEN1 (0.40) | MEN1KMT2AADRB1ADRB3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115706-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | claimed |
| WO-2000018730-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | claimed |
| EP-1115706-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018730-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |