Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28096910 | 0.81 | HTT (0.46) | HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7770044 | 0.81 | HTT (0.39) | HTTMAOAMAOB | |
| SCHEMBL7769991 | 0.80 | HTT (0.42) | HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7773705 | 0.79 | ACHE (0.39) | HTTMAOAMAOBSMN1; SMN2ALDH1A1 | |
| SCHEMBL24687424 | 0.79 | HTT (0.48) | HTTNPC1RAB9ASMN1; SMN2CA1 | |
| SCHEMBL7769633 | 0.78 | MAOA (0.40) | HTTMAOAMAOBSMN1; SMN2CA2 | |
| SCHEMBL1783247 | 0.77 | HTT (0.46) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14001450 | 0.76 | HTT (0.42) | HTTMAOBSMN1; SMN2CA1CA2 | |
| SCHEMBL967570 | 0.75 | HTT (0.45) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11173967 | 0.74 | HTT (0.48) | HTTCA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |