Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.48 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.48 |
| ▸ | CHRM4 known ✓ | P08173 | 5/20 | 0.48 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.48 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777033 | 0.99 | CHRM1 (0.47) | CHRM1CHRM3CHRM4CHRM2THRB | |
| SCHEMBL28033038 | 0.81 | THRB (0.49) | CHRM1CHRM3CHRM4CHRM2THRB | |
| Hydrochloric Acid SCHEMBL28000634 | 0.80 | THRB (0.48) | CHRM1CHRM3CHRM4CHRM2THRB | |
| Benzophenone SCHEMBL1371756 | 0.77 | THRB (0.54) | CHRM1CHRM3CHRM4CHRM2THRB | |
| Benzophenone SCHEMBL3410520 | 0.74 | THRB (0.54) | CHRM1CHRM3CHRM4CHRM2THRB | |
| SCHEMBL28290653 | 0.73 | THRB (0.47) | CHRM1CHRM3CHRM4CHRM2THRB | |
| Bromide SCHEMBL29236904 | 0.73 | THRB (0.53) | CHRM1CHRM3CHRM4CHRM2THRB | |
| Hydrochloric Acid SCHEMBL169126 | 0.73 | THRB (0.49) | CHRM1CHRM3CHRM4CHRM2THRB | |
| Bromide SCHEMBL645587 | 0.73 | CES2 (0.43) | CHRM1CHRM3CHRM4CHRM2LMNA | |
| Benzoin SCHEMBL11764629 | 0.72 | LMNA (0.54) | CHRM1CHRM3CHRM4CHRM2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877298-B1 | Coated xerographic photographic paper | XEROX CORP (US) | 2001-08-29 | — | — | EP | claimed |
| US-5908723-A | Recording sheets | XEROX CORPORATION (US) | 1999-06-01 | — | — | US | claimed |
| US-5908723-A | Recording sheets | XEROX CORPORATION (US) | 1999-06-01 | — | — | US | disclosed |