Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672587 | 0.90 | LMNA (0.46) | RAB9AMEN1KMT2ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL6676863 | 0.89 | LMNA (0.46) | RAB9AMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL7771958 | 0.85 | MAPT (0.46) | RAB9AL3MBTL1LMNAMAPTSIGMAR1 | |
| SCHEMBL8862446 | 0.82 | LMNA (0.46) | RAB9AMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL7771967 | 0.82 | SIGMAR1 (0.46) | RAB9ASMN1; SMN2LMNAMAPTSIGMAR1 | |
| SCHEMBL7771965 | 0.81 | DRD2 (0.52) | RAB9ALMNAMAPTSIGMAR1DRD3 | |
| SCHEMBL7767918 | 0.81 | LMNA (0.53) | RAB9AMEN1KMT2ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL7796036 | 0.80 | LMNA (0.52) | RAB9AMEN1KMT2ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL7920769 | 0.80 | LMNA (0.52) | RAB9AMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL6677425 | 0.80 | DRD2 (0.46) | RAB9AMEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658910-A | TREATING MENTAL DISORDERS | PHARMACIA AB (SE) | 1997-08-19 | — | — | US | claimed |
| EP-1120410-A1 | Nicotinic acid esters useful as CNS agents and having affinity for 5-HT receptors | Pharmacia AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| US-5658910-A | TREATING MENTAL DISORDERS | PHARMACIA AB (SE) | 1997-08-19 | — | — | US | disclosed |
| EP-0673368-A1 | NOVEL NICOTINIC ACID ESTERS | Pharmacia & Upjohn Aktiebolag (SE) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994000434-A1 | NOVEL NICOTINIC ACID ESTERS | KABI PHARMACIA AB (SE) | 1994-01-06 | — | — | WO | disclosed |