Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8956567 | 0.95 | PKM (0.46) | PKMKCNA3ALDH1A1LMNAHSD17B10 | |
| SCHEMBL14374689 | 0.79 | PKM (0.57) | PKMKCNA3ALDH1A1LMNAHSD17B10 | |
| Hydrochloric Acid SCHEMBL9156425 | 0.76 | ALDH1A1 (0.45) | KCNA3ALDH1A1LMNAHPGDKDM4E | |
| Hydrochloric Acid SCHEMBL9156421 | 0.76 | ALDH1A1 (0.45) | KCNA3ALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL20567484 | 0.76 | PKM (0.54) | PKMKCNA3ALDH1A1LMNAHSD17B10 | |
| SCHEMBL9786855 | 0.75 | PKM (0.49) | PKMKCNA3ALDH1A1LMNAHSD17B10 | |
| SCHEMBL28297387 | 0.75 | PKM (0.49) | PKMKCNA3ALDH1A1LMNAHSD17B10 | |
| SCHEMBL13240433 | 0.75 | PKM (0.49) | PKMKCNA3ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8956475 | 0.73 | PKM (0.51) | PKMKCNA3ALDH1A1LMNAHSD17B10 | |
| Hydrochloric Acid SCHEMBL7766664 | 0.73 | KDM4E (0.34) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775192-B1 | BLEACHING COMPOSITIONS CONTAINING IMINE, PEROXIDE COMPOUND AND A TRANSITION METAL CATALYST | UNILEVER NV (NL) | 2001-08-01 | — | — | EP | disclosed |
| US-5785886-A | ENHANCED BLEACH PERFORMANCE | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1998-07-28 | — | — | US | disclosed |
| US-5653910-A | SYNERGISTIC MIXTURE | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO INC. (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0775192-A1 | BLEACHING COMPOSITIONS CONTAINING IMINE, PEROXIDE COMPOUND AND A TRANSITION METAL CATALYST | UNILEVER N.V. (NL) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996040855-A1 | BLEACHING COMPOSITIONS CONTAINING IMINE, PEROXIDE COMPOUND AND A TRANSITION METAL CATALYST | UNILEVER N.V. (NL) | 1996-12-19 | — | — | WO | disclosed |
| US-5463115-A | Enhance bleaching action of peroxygen compounds | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0446982-B1 | Low-temperature bleaching compositions | UNILEVER NV (NL) | 1994-10-26 | — | — | EP | disclosed |
| EP-0453003-B1 | Bleach catalysts and compositions containing same | UNILEVER NV (NL) | 1994-10-05 | — | — | EP | disclosed |
| EP-0453003-A2 | Bleach catalysts and compositions containing same | UNILEVER N.V. (NL) | 1991-10-23 | — | — | EP | disclosed |
| EP-0446982-A2 | Low-temperature bleaching compositions | UNILEVER N.V. (NL) | 1991-09-18 | — | — | EP | disclosed |
| US-5047163-A | Low Temperature Bleaching Composition Containing A Peroxygen Compound, A Sulfonimine Oxygen Transfer Agent Activator And A! Bleach Percursor | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1991-09-10 | — | — | US | disclosed |
| US-5041232-A | Inlcudes peroxygen compound and surfactant | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1991-08-20 | — | — | US | disclosed |