Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8981580 | 0.82 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| Water SCHEMBL44003 | 0.81 | NPC1 (0.35) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7535852 | 0.80 | LMNA (0.38) | KMT2ALMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL9647040 | 0.79 | EGLN2 (0.40) | ALDH1A1JAK1PKMPOLB | |
| SCHEMBL21401818 | 0.76 | SMN1; SMN2 (0.39) | LMNAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| Water SCHEMBL28325020 | 0.75 | L3MBTL1 (0.40) | KMT2ALMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL28683669 | 0.73 | CYP3A4 (0.47) | KMT2ALMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL4271408 | 0.73 | L3MBTL1 (0.41) | KMT2ALMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9685247 | 0.73 | NPC1 (0.37) | SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL11702489 | 0.73 | RAB9A (0.37) | KMT2ALMNAMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574906-B1 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO (JP) | 2001-08-22 | — | — | EP | disclosed |
| US-5380724-A | Inhibitors of lipid peroxidation | GYOGYSZERKUTATO INTEZET KFT (HU) | 1995-01-10 | — | — | US | disclosed |
| EP-0574906-A2 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-12-22 | — | — | EP | disclosed |