SCHEMBL7776573

SCHEMBL7776573

COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)C[C@@]2(O)[Si](C)(C)C(C)(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DUT P33316 9/20 0.41
TYMP P19971 2/20 0.39
NT5E P21589 1/20 0.38
SLC6A1 P30531 2/20 0.35
SLC6A11 P48066 1/20 0.35
P2RY14 Q15391 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
HSP90AA1 P07900 1/20 0.33
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9109482 0.83 NT5E (0.39) DUTTYMPNT5ESLC6A1SLC6A11
SCHEMBL13493930 0.78 DUT (0.42) DUTTYMPNT5ESLC6A1SLC6A11
SCHEMBL912657 0.77 DUT (0.60) DUTTYMPP2RY14
SCHEMBL13463839 0.77 DUT (0.60) DUTTYMPP2RY14
SCHEMBL912656 0.77 DUT (0.60) DUTTYMPP2RY14
SCHEMBL19841219 0.77 DUT (0.60) DUTTYMPP2RY14
SCHEMBL14403996 0.77 DUT (0.60) DUTTYMPP2RY14
SCHEMBL13444851 0.77 DUT (0.60) DUTTYMPP2RY14
SCHEMBL7776576 0.77 DUT (0.45) DUTTYMPP2RY14MEN1KMT2A
SCHEMBL6312752 0.77 DUT (0.45) DUTTYMPP2RY14MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0423839-B1 Polynucleotides and probes useful in solution phase nucleic acid sandwich assay BAYER AG (US) 2001-08-16 EP disclosed
EP-0225807-B1 Solution phase nucleic acid sandwich assay and polynucleotide probes useful therein CHIRON CORP (US) 1994-10-19 EP disclosed
US-5093232-A Detection of dna sequences CHIRON CORPORATION (US) 1992-03-03 US disclosed
EP-0423839-A2 Polynucleotides and probes useful in solution phase nucleic acid sandwich assay CHIRON CORPORATION (US) 1991-04-24 EP disclosed
US-4910300-A Adding additional nucleotide to modified nucleotide at CHIRON CORPORATION (US) 1990-03-20 US disclosed