Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.64 |
| ▸ | CDK2 | P24941 | 11/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771263 | 0.81 | EGFR (0.52) | CDK4CDK2MEN1KMT2AEGFR | |
| SCHEMBL7777355 | 0.77 | NPC1 (0.54) | CDK4CDK2MEN1KMT2ANPC1 | |
| SCHEMBL1387422 | 0.77 | EGFR (0.65) | CDK4CDK2MEN1KMT2ANPC1 | |
| SCHEMBL7778617 | 0.71 | EGFR (0.64) | CDK4CDK2MEN1KMT2ANPC1 | |
| SCHEMBL4317286 | 0.70 | ALDH1A1 (0.67) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL11774653 | 0.70 | ALDH1A1 (0.58) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1891437 | 0.69 | KDR (0.69) | TNNI3K | |
| SCHEMBL2177484 | 0.68 | EGFR (0.57) | CDK4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7777444 | 0.68 | EGFR (0.57) | EGFRERBB3 | |
| SCHEMBL7778702 | 0.68 | MEN1 (0.51) | CDK4MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |