Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780171 | 0.80 | KDM4E (0.55) | KDM4ERAB9ANPC1TDP1MEN1 | |
| SCHEMBL25738291 | 0.78 | CA12 (0.57) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL622328 | 0.78 | KDM4E (0.47) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL31078939 | 0.75 | RAB9A (0.49) | KDM4ERAB9ANPC1TDP1MEN1 | |
| SCHEMBL14652405 | 0.75 | MAPT (0.53) | RAB9ANPC1MEN1KMT2AL3MBTL1 | |
| SCHEMBL17652044 | 0.74 | SMN1; SMN2 (0.64) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL17024452 | 0.74 | LMNA (0.53) | KDM4EKMT2AALDH1A1PSEN1PSEN2 | |
| SCHEMBL4160781 | 0.74 | ALDH1A1 (0.60) | KDM4ERAB9ANPC1TDP1MEN1 | |
| SCHEMBL6654340 | 0.74 | LMNA (0.58) | KDM4ERAB9ANPC1TDP1MEN1 | |
| SCHEMBL5515918 | 0.74 | PSEN1 (0.49) | RAB9ANPC1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135377-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034254-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | disclosed |