Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | TACR3 | P29371 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27557704 | 0.81 | TRPA1 (0.30) | TRPA1 | |
| SCHEMBL4624447 | 0.76 | MEN1 (0.37) | KMT2AMEN1ALDH1A1MAPTITGA4 | |
| SCHEMBL28679428 | 0.74 | MAPT (0.38) | KMT2AMEN1ALDH1A1MAPTITGA4 | |
| SCHEMBL7782980 | 0.72 | ALDH1A1 (0.31) | ALDH1A1MAPTITGA4 | |
| SCHEMBL38654837 | 0.69 | LMNA (0.31) | HTTLMNA | |
| Hydrochloric Acid SCHEMBL27684552 | 0.69 | PDE7A (0.31) | ALDH1A1MAPTITGA4TRPA1 | |
| SCHEMBL27871252 | 0.69 | — | — | |
| SCHEMBL4625185 | 0.68 | MAPT (0.34) | KMT2AALDH1A1MAPTITGA4TRPA1 | |
| SCHEMBL28846712 | 0.67 | — | — | |
| SCHEMBL28330586 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552329-B1 | METHYLEN-OXINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 2001-10-04 | — | — | EP | disclosed |
| US-5409949-A | Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-04-25 | — | — | US | disclosed |
| EP-0552329-A1 | METHYLEN-OXINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| EP-0525472-A2 | Methylen-oxindole derivatives and process for their preparation | PHARMACIA S.p.A. (IT) | 1993-02-03 | — | — | EP | disclosed |
| WO-1993001182-A1 | METHYLEN-OXINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1993-01-21 | — | — | WO | disclosed |